A group of researchers from India and France was able to achieve full restoration of long-term memory in mice with Alzheimer’s disease with the help of synthesized therapeutic molecules attached to carbon nanoshe.
Initially, scientists have created a special substance that activates two enzymes (CBP and P300 Histone Acetyltransferases), contributing to the regeneration of brain neurons and prevents their destruction. Their presence also activates several genes that are important for memory. During the tests, experimental mice did not only have the restoration of 81% of destroyed cells, but also the formation of new links, memory normalization, reduced load on previous neurons.
However, despite the unique therapeutic properties, the molecules of the substance could not overcome the hematostephalic barrier and get into the brain, so the command began to look for a solution for transportation. They became carbon spheres with a diameter of 400 nm, which are created using glucose.
Therapeutic molecules are attached to the surface of the nanosphere, together with which they achieve the necessary parts of the brain. The effect of penetration becomes possible due to the fact that carbon spheres partially retain the glucose properties that cells feed. Nonosphere with medicine reaches the brain 48-72 hours after the introduction into the body and delay there about 21 days.
In addition to the treatment of Alzheimer’s disease, technology can be used to combat other damage to neurons, memory and neurogeneration. So far, the JNCASR team explores the long-term effect of components on the body and possible side effects from the application. In the future, they plan to launch their own startup.
Researchers from the North-West University of St. Louis are also engaged in fabric regeneration issues. They developed